id author title date pages extension mime words sentences flesch summary cache txt cord-344446-5d7yuoz1 Naughton, Sean X. The role of the exposome in promoting resilience or susceptibility after SARS-CoV-2 infection 2020-05-12 .txt text/plain 754 45 46 One of the more perplexing aspects of the recent SARS-CoV-2 pandemic is the high level of variability among patients in terms of disease severity. Exposure to environmental toxins as well as lifestyle choices can affect ACE2 expression, and may possibly increase the severity of infection. For example, exposure to ultrafine particulate matter from air pollution (PM 2.5) has previously been shown to increase the expression of ACE2 [4] . In line with these findings, a recent report indicates that higher levels of air pollution may be a contributing factor to the increased fatality rate among COVID-19 patients in northern Italy [5] . Dietary/lifestyle factors may also play a role in determining resilience or susceptibility to severe outcomes after SARS-CoV-2 infection. Thus, it is possible that multiple independent variables may affect ACE2 expression and thereby confer resilience or susceptibility towards severe life-threatening conditions after SARS-Cov-2 infection. ./cache/cord-344446-5d7yuoz1.txt ./txt/cord-344446-5d7yuoz1.txt