id author title date pages extension mime words sentences flesch summary cache txt cord-344330-zsx7wfyj Su, Shuo Epidemiology, Genetic Recombination, and Pathogenesis of Coronaviruses 2016-03-21 .txt text/plain 4537 227 49 Since then, more HCoVs have been discovered, including those that cause severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS), two pathogens that, upon infection, can cause fatal respiratory disease in humans. In this review we aim to compare and contrast the different HCoVs with regard to epidemiology and pathogenesis, in addition to the virus evolution and recombination events which have, on occasion, resulted in outbreaks amongst humans. In humans, CoV infections primarily involve the upper respiratory tract and the gastrointestinal tract, and vary from mild, self-limiting disease, such as the common cold, to more severe manifestations, such as bronchitis and pneumonia with renal involvement [15] . A recent investigation discovered that multiple HCoV species, including MERS-CoV, beta-CoV group A, and a 229E-like virus, circulate amongst dromedary camels in Saudi Arabia [62] . Clinical features and virological analysis of a case of Middle East respiratory syndrome coronavirus infection ./cache/cord-344330-zsx7wfyj.txt ./txt/cord-344330-zsx7wfyj.txt