id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-343919-n8884bli	Salvio, Gianmaria	Bone Metabolism in SARS-CoV-2 Disease: Possible Osteoimmunology and Gender Implications	2020-09-01		.txt	text/plain	3908	183	39	We present a brief review of the molecular mechanisms linking inflammatory diseases to increased fracture risk/osteoporosis and of the therapeutic strategies that can prevent bone resorption in patients with inflammatory disease, focusing on the RANK-RANKL system. A subsequent in vitro study showed that a specific SARS-CoV protein, 3a/X1, directly promotes osteoclastogenesis, accelerating osteoclast differentiation from monocyte/macrophage precursors, enhancing the expression of receptor activator of NF-kB ligand (RANKL) and inflammatory cytokines such as TNF-α, which indirectly promote osteoclastogenesis [20] . As will be explained later in the text, IL-6 represents an important cofactor for bone resorption in inflammatory diseases; therefore, during SARS-CoV-2 infection, men, though less affected by osteoporosis, may experience more bone metabolism alterations than women for higher levels of IL-6 resulting from the lack of suppression by estrogen.	./cache/cord-343919-n8884bli.txt	./txt/cord-343919-n8884bli.txt