id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-343864-0258nh92	Straughn, Alex R.	Withaferin A: a potential therapeutic agent against COVID-19 infection	2020-07-19		.txt	text/plain	2916	141	45	Therefore, WFA demonstrates real potential as a therapeutic agent to treat or prevent the spread of COVID-19 due to the reported interference in viral S-protein to host receptor binding and its lack of effect on ACE2 expression in the lungs. Data from four SARS-CoV-2 hot spots (the United States, Italy, Spain and China) has shown that cancer patients infected with the novel coronavirus have a significantly increased risk of admission to an intensive care unit (ICU) and/or requiring mechanical ventilation, as well as an increase in patient mortality [15, [17] [18] [19] . Withaferin A alone or in combination with drugs, such as: hydroxychloroquine, dexamethasone or other treatments (under clinical trials), could be developed into an attractive therapeutic agent for both the general population and cancer patients due to its anti-tumorigenic properties and the preliminary studies showing that it is capable of binding to the Sprotein of SARS-CoV-2, thereby potentially inhibiting infection and/or spread of the disease.	./cache/cord-343864-0258nh92.txt	./txt/cord-343864-0258nh92.txt