id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-343455-v1648kng	Zhu, Na	Morphogenesis and cytopathic effect of SARS-CoV-2 infection in human airway epithelial cells	2020-08-06		.txt	text/plain	4132	237	49	Here, we characterize the replication dynamics, cell tropism and morphogenesis of SARS-CoV-2 in organotypic human airway epithelial (HAE) cultures. SARS-CoV-2 replicates efficiently and infects both ciliated and secretory cells in HAE cultures. In this study, we compared the characteristics of the replication dynamics, cell tropism, and morphogenesis of SARS-CoV-2 and HCoV-NL63 in HAE cells, which express the shared receptor, to better understand the pathogenesis and transmission of SARS-CoV-2. As shown in Fig. 1a , HAE cells were highly susceptible to SARS-CoV-2 infection with peak virus production from apical wash at 48-72 h post infection (h pi) and remained at a high level from 3 to 6 days. As shown in Fig. 1c , virus particles were found on the apical surface of both ciliated cells and secretory cells; inclusion bodies formed by viral components were observed in the cytoplasm, which confirmed the infection of both cell types.	./cache/cord-343455-v1648kng.txt	./txt/cord-343455-v1648kng.txt