id author title date pages extension mime words sentences flesch summary cache txt cord-343192-fkc7af9y Chen, Siyang Comment on “Central Nervous System Involvement by Severe Acute Respiratory Syndrome Coronavirus ‐2 (SARS‐CoV‐2)” 2020-05-08 .txt text/plain 1197 69 45 We read the article "Central Nervous System Involvement by Severe Acute Respiratory Syndrome Coronavirus -2 (SARS-CoV-2)" with great interest. Although there have been several reports previously suggesting that the similar SARS-CoV-2 virus could infect neuronal cells and cause central and peripheral neurological morbidities in COVID-19 patients (3) (4) (5) , few direct detection of virus by RT-PCR in cerebrospinal fluid (CSF) has casted earlier doubt whether there is indeed a direct infection of central nervous system (CNS). It is not clear whether SARS-CoV-2 viruses can be similarly detected in endothelial cells from other severe COVID-19 patients with central neurological involvement (3). It is worthy to point out that one very recent report from a Chinese case demonstrating the presence of SARS-CoV-2 virus sequence in the CSF fluid of a COVID-19 patient presenting viral encephalitis (7) . Central Nervous System Involvement by Severe Acute Respiratory Syndrome Coronavirus -2 (SARS-CoV-2) ./cache/cord-343192-fkc7af9y.txt ./txt/cord-343192-fkc7af9y.txt