id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-343127-n3fs8ph8	Pousa, Pedro A.	Extrapulmonary manifestations of COVID-19 in children: a comprehensive review and pathophysiological considerations	2020-09-22		.txt	text/plain	5503	318	46	OBJECTIVE: The aim of this review was to summarize the most common extrapulmonary manifestations in pediatric patients with COVID-19, as well as to discuss clinical, epidemiological, and pathophysiological aspects of these clinical presentations in children. In addition, epithelial cells of the small intestine is another tissue that highly express ACE2 in cell membrane, [42] creating another potential region for SARS-CoV-2 infection and enteric manifestations of COVID-19. Hence, the present authors speculate that, although children and adults have similar rates of GI symptoms, children GI symptoms are usually associated as a primary response of SARS-CoV-2 infection, due to this minor expression of ACE2, and represent milder symptoms. Children are susceptible to liver injury, as shown by a meta-analysis of 551 laboratory-confirmed pediatric COVID-19 patients reporting that 9% (35/290) presented increased ALT and 18% (58/280), high levels of AST. Therefore, children might present less severe cases of kidney injury associated with COVID-19 due to this greater expression of AT2R than adults.	./cache/cord-343127-n3fs8ph8.txt	./txt/cord-343127-n3fs8ph8.txt