id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-343043-piyt3i0h	Baker, S. A.	Angiotensin-converting enzyme 2 (ACE2) expression increases with age in patients requiringmechanical ventilation.	2020-07-07		.txt	text/plain	4608	268	47	In non-ventilated individuals, AT2 cell reactive changes were not observed and ACE2 expression did not change with age when normalized to lung area (p = 0.231) or cellularity (p = 0.349). In summary, ACE2 expression increases with age in the setting of alveolar damage observed in patients on mechanical ventilation, providing a potential mechanism for higher Covid-19 mortality in the elderly. Given that the mechanism of death in Covid-19 typically involves severe lower respiratory tract infection, a disease feature strongly correlated with age, previous studies have sought to connect lung ACE2 expression with aging 28, 29 . If lung ACE2 expression is triggered by mechanical ventilation itself via inflammatory cytokine production, then these factors may predispose older individuals to severe SARS-CoV-2 infection. In this small series of cases, we identified increased ACE2 RNA and ACE2 protein expression within the human lung associated with age, when controlling for ventilator status.	./cache/cord-343043-piyt3i0h.txt	./txt/cord-343043-piyt3i0h.txt