id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-342220-lrqt2gcw	Dearlove, Bethany	A SARS-CoV-2 vaccine candidate would likely match all currently circulating variants	2020-09-22		.txt	text/plain	7874	415	49	Although the closest currently available bat sequences are fairly divergent from SARS-CoV-2, their characteristics (insertion at S1/S2 cleavage site, high diversity, and similarity between specific gene fragments and particular strains) together with their known adaptive properties (high recombination and host-switching rates and evidence of positive selection) support that these bat viruses constitute While the evolutionary rate is likely to decrease over time (18) , it is important to monitor the introduction of any mutation that may compromise the potential efficacy of vaccine candidates derived from the first available SARS-CoV-2 sequences. In S, only site 614 was estimated to be under diversifying selection in a majority of subsampled alignments (58%); evidence of diversifying selection indicates that genetic diversity increases in the viral population (i.e., there was a higher proportion of mutations causing an amino acid change than not at site 614, or, the nonsynonymous/synonymous substitution rates ratio, dN/dS, was over 1, P < 0.1) (SI Appendix, Fig. S4 ).	./cache/cord-342220-lrqt2gcw.txt	./txt/cord-342220-lrqt2gcw.txt