id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-342177-iqt3ghc0	Laine, Roger A	The case for re-examining glycosylation inhibitors, mimetics, primers and glycosylation decoys as antivirals and anti-inflammatories in COVID19	2020-08-21		.txt	text/plain	3060	198	39	1974) and in 1976 showed that tunicamycin, which inhibits the formation of N-acetylglucosamine-lipid intermediates in N-linked glycan synthesis (Lennarz 1975) , suppressed glycoprotein synthesis in Semliki Forest, influenza and avian sarcoma virus (Schwarz et al. The "peplomeric glycoprotein E2 was not detectable upon tunicamycin treatment," indicating its synthesis was interdicted or its degradation was facilitated by lack of N-linked glycosylation and was improperly processed (Holmes et al. (1982) showed swainsonine, an α-mannosidase inhibitor, to inhibit processing of oligosaccharides on influenza viral hemagglutinin, and in 1983 showed its effect on vesicular stomatitis virus (Kang and Elbein 1983) . It seems a reasonable approach that interfering with host glycosylation systems hijacked by SARS COV2, plus interfering with the ACE2 receptor glycosylation may combine to 1) interdict infectivity and 2) glycosylation interference with Sialyl LeX can inhibit E-selectin-based inflammatory responses, mitigating the Covid19 ARDS pathology. Antiviral effect of alpha-glucosidase inhibitors on viral morphogenesis and binding properties of hepatitis C virus-like particles	./cache/cord-342177-iqt3ghc0.txt	./txt/cord-342177-iqt3ghc0.txt