id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-341453-9yrvjlpx	Clay, Candice C	Severe acute respiratory syndrome-coronavirus infection in aged nonhuman primates is associated with modulated pulmonary and systemic immune responses	2014-03-19		.txt	text/plain	8130	395	48	The aim of this study was to determine how the peripheral and mucosal immune responses to SARS-CoV infection compare in the aged and juvenile nonhuman primate host and to determine how this may impact viral replication levels. No virus was detected in any sample collected from either age group at 10 d.p.i. To determine if advanced age correlated with increased severity of lung pathology, a comprehensive histological analysis of the respiratory tract following SARS-CoV infection was conducted in aged and juvenile animals. To determine how mucosal cytokines in SARS-CoV infection compared to systemic responses and how age may impact mucosal cytokine expression; the inflammatory protein profile was evaluated by bead-based arrays in standardized-collected lung tissue from the proximal portion of the right caudal lobe. Although no age-dependent differences were observed in the frequency of naïve (CD45RA + CCR7+) CD8 T cells in peripheral blood, there were significantly lower levels of these cells in the lung and lymph node of aged animals during SARS-CoV infection ( Figure 6A -C; unpaired student T-tests).	./cache/cord-341453-9yrvjlpx.txt	./txt/cord-341453-9yrvjlpx.txt