id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-341176-83khavoh	Lotfi, Melika	CRISPR/Cas13: A potential therapeutic option of COVID-19	2020-09-17		.txt	text/plain	5287	274	49	In contrast to traditional vaccines and therapies, which rely on priming the human immune system to identify viral proteins and components and reduce viral entrance into cells (12) , the CRISPR-based system has focused on identifying and degrading the intracellular viral genome and its resulting viral mRNAs. Thus, for using CRISPR as a therapeutic option, it is critical to identify the SARS-CoV-2 molecular characteristics. They found that the two highly-conserved regions in SARS-CoV-2 genome, which can be appropriate to be targeted by PAC-MAN as a potential pan-coronavirus inhibition strategy are respectively the RNA-dependent RNA polymerase (RdRP) gene in the open reading frame1a/b or ORF1a/b region, which maintains the proliferation of all coronaviruses, and the Nucleocapsid (N) gene at the 3' end of the genome, which encodes the capsid protein for viral packaging (13) .	./cache/cord-341176-83khavoh.txt	./txt/cord-341176-83khavoh.txt