id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-341045-75of9ys6	Shah, Abdullah	Genetic characterization of structural and open reading Fram-8 proteins of SARS-CoV-2 isolates from different countries	2020-09-14		.txt	text/plain	1041	64	56	By multiple sequence alignment of amino acids, we observed substitutions and deletion in S protein at 13 different sites in the isolates of five countries (China, USA, Finland, India and Australia) as compared to the reference sequence. Interestingly, in ORF8 substitution of Leucine, a nonpolar to Serine a polar amino acid at same position (aa84 L to S) in 23 isolates of five countries i.e. China, USA, Spain, Taiwan and India were observed, which may affect the conformation of peptides. Thus, we observed several mutations in the isolates thereafter the first sequencing of SARS-CoV-2 isolate, NC_045512.2, which suggested that this virus might be a threat to the whole world and therefore further studies are needed to characterize how these mutations in different proteins affect the functionality and pathogenesis of SARS-CoV-2. Thus, further studies are required to characterize how these amino acids substitutions in different proteins affect the functionality and pathogenesis of SARS-CoV-2.	./cache/cord-341045-75of9ys6.txt	./txt/cord-341045-75of9ys6.txt