id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-339625-ucfjo73c	Qiu, Xiang	Calreticulin as a hydrophilic chimeric molecular adjuvant enhances IgG responses to the spike protein of severe acute respiratory syndrome coronavirus	2012-07-26		.txt	text/plain	3586	178	55	Given that rCRT/39–272 can drive the maturation of bone‐marrow‐derived dendritic cells, directly activate macrophages and B cells, and also elicit helper T cell responses in vivo, we propose that fragment 39–272 of CRT is an effective molecular adjuvant capable of enhancing target Ag‐specific humoral responses in both a T cell‐dependent and independent manner. By using DNA vaccines encoding fusion proteins between CRT and target antigens such as tumor antigen E7, N protein of SARS-CoV and Bacillus anthracis protective antigen domain IV, previous investigators have also observed that CRT can function as a molecular adjuvant (13) (14) (15) (16) . Cheng and colleagues found that intradermal immunization with a DNA vaccine encoding a fusion protein between CRT, or CRT fragments, and the E7 tumor antigen was more efficient at eliciting E7-specific CD8 + T cells and protecting against E7-expressing tumors in C57BL/6 mice (13, 14) .	./cache/cord-339625-ucfjo73c.txt	./txt/cord-339625-ucfjo73c.txt