id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-339521-qfnu319w	Lin, Shiming	Surface ultrastructure of SARS coronavirus revealed by atomic force microscopy	2005-08-08		.txt	text/plain	3647	220	58	Here, we used AFM to determine the surface ultra structure of each single SARS-CoV virion and observe the surface characteristics and their topography and phase changes after treatments with hydroxyoctanoic acid or protease. The higher-resolution image shows that many individual spherical protrusions exist on the surface and the corresponding cursor profile (Fig. 1 a ) clearly reveals the presence of SARS-CoV particles and each single particle is readily distinguishable. The corresponding cursor profile provides quantitative measurements of the heights for the SARS-CoV particles on the surface. It was found that from the contour map (Fig. 5C ) 15 spike proteins (arrowheads) surround the envelope of a single SARS-CoV virion. The phase image provides a measure of sample heterogeneity and also indicates that the small spherical particles (arrowheads) come from the SARS-CoV virion itself (Fig. 6B) .	./cache/cord-339521-qfnu319w.txt	./txt/cord-339521-qfnu319w.txt