id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-339019-vgnxhksv	Lee, Ting-Wai	Crystal Structures Reveal an Induced-fit Binding of a Substrate-like Aza-peptide Epoxide to SARS Coronavirus Main Peptidase	2007-02-23		.txt	text/plain	8447	450	62	We report two crystal structures of Mpro having an additional Ala at the N terminus of each protomer (M+A(-1) pro), both at a resolution of 2.00 Å, in space group P43212: one unbound and one bound by a substrate-like aza-peptide epoxide (APE). 25 We have now grown crystals of M pro in the same space group (P2 1 with the same unit-cell constants) at pH 6.0 under slightly different conditions; the active sites and the S1 specificity pockets of both protomers are in the catalytically competent conformation (Figures 2(a) and (b), 3(a) and (b), 4(a) and (b)). Active sites and substrate-binding regions of the unbound SARS-CoV M +A(-1) pro We have reported the crystal structure of the SARS-CoV M +A (-1) pro :APE complex in space group P2 1 2 1 2 1 , whose asymmetric unit contains both protomers of the M +A(-1) pro dimer.	./cache/cord-339019-vgnxhksv.txt	./txt/cord-339019-vgnxhksv.txt