id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-337962-9le56say	Duan, Fuyu	Modeling COVID-19 with Human Pluripotent Stem Cell-Derived Cells Reveals Synergistic Effects of Anti-inflammatory Macrophages with ACE2 Inhibition Against SARS-CoV-2	2020-08-20		.txt	text/plain	5337	262	51	Here, we used directed differentiation of human pluripotent stem cells (hPSCs) to establish a lung and macrophage co-culture system and model the host-pathogen interaction and immune response caused by SARS-CoV-2 infection. Recent studies (Liao et al., 2020; Xu et al., 2020) on immunity of COVID-19 patients indicate that the cells damaged by SARS-CoV-2 infection induced innate in ammation in the lungs that is largely mediated by pro-in ammatory macrophages and granulocytes. To further characterize at the transcriptomic level the response of iLung and iMφ following viral infection, scRNA-seq was performed on the co-cultures with SARS-CoV-2 pseudo virus infection and the analysis revealed that a set of anti-in ammatory factors and anti-viral activity related genes, such as CCL26, CCL13, ISG15, IFITM2 and IFITM3, were clearly upregulated when cultures contained M2-iMφ ( Figure 4A and C, Figures S8A) .	./cache/cord-337962-9le56say.txt	./txt/cord-337962-9le56say.txt