id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-337602-5evfkk70	Focosi, Daniele	Anti‐A Isohemagglutinin titers and SARS‐CoV2 neutralization: implications for children and convalescent plasma selection	2020-06-09		.txt	text/plain	1163	55	44	. Most importantly, the Italian-Spanish genome-wide association study identified the rs657152 polymorphism in the ABO locus on chromosome 9q34 (and only another polymorphism in chromosome 3p21.31) as the only susceptibility locus for respiratory failure in COVID-19 (6) , suggesting that, in addition to disease acquisition, ABO blood group could also affect disease severity. If confirmed, this hypothesis will have implications for convalescent plasma therapy, since anti-A1 IgG could confer additional benefit over anti-SARS-CoV2 neutralizing antibodies: in fact, while preserving ABO match compatibility, it could be wiser to prefer blood group O donors for CP in COVID-19. All rights reserved Accepted Article considered that hyperimmune serum, arising from pooled diverse ABO groups, contains far lower anti-A isoagglutinin titer than an average O-group convalescent donation. The ABO blood group locus and a chromosome 3 gene cluster associate with SARS-CoV-2 respiratory failure in an Italian-Spanish genome-wide association analysis	./cache/cord-337602-5evfkk70.txt	./txt/cord-337602-5evfkk70.txt