id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-337179-qytruuif	Guazzi, Marco	The Dilemma of Renin Angiotensin System Blockers in Coronavirus Disease (Covid‐19): Insights on the Lung Fluid Handling and Gas Exchange in Heart Failure Patients	2020-05-21		.txt	text/plain	1887	109	43	title: The Dilemma of Renin Angiotensin System Blockers in Coronavirus Disease (Covid‐19): Insights on the Lung Fluid Handling and Gas Exchange in Heart Failure Patients The main clinical manifestation of SARS-CoV-2 is severe acute respiratory syndrome which yields to inflammatory reaction and alveolar fluid floading ultimately impairing gas exchange. We gained previous experience on the effects of renin-angiotensin system inhibition on the pulmonary function of HF patients showing a protective effect on the perturbed gas exchange and lung fluid handling, i.e. alveolar capillary stress-failure, an effect especially observed with enalapril treatment, with a positive but statistically not signfiicnat trend for losartan 11, 12 . Based on this, we outline how renin angiotensin blockers may interact with the lung fluid handling and gas diffusion process in patients with HF infected by SARS-CoV-2, and propose areas for further research.	./cache/cord-337179-qytruuif.txt	./txt/cord-337179-qytruuif.txt