id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-337093-7pxfzuq0	Hess, David C.	COVID-19-Related Stroke	2020-05-07		.txt	text/plain	1846	118	49	The SARS-CoV-2 virus binds to angiotensin-converting enzyme 2 (ACE2) present on brain endothelial and smooth muscle cells. Depletion of ACE2 by SARS-CoV-2 may tip the balance in favor of the "harmful" ACE1/angiotensin II axis and promote tissue injury including stroke. There is a rationale to continue to treat with tissue plasminogen activator for COVID-19-related stroke and low molecular weight heparinoids may reduce thrombosis and mortality in sepsis-induced coagulopathy. The SARS-CoV-2 virus binds to the angiotensin-converting enzyme 2 (ACE2) via its spike (S) protein [9] . The depletion of ACE2 by the SARS-CoV-2 virus coupled with the age-related decline in ACE2 and increase of ACE-1-Ang II tips the balance in favor of ACE-1/ angiotensin II with proinflammatory and organ damaging effects. Binding to and depletion of ACE2 may tip the RAS balance in favor of the ACE-1-angiotensin II-AT1 axis and contribute to endothelial dysfunction, organ damage, and stroke.	./cache/cord-337093-7pxfzuq0.txt	./txt/cord-337093-7pxfzuq0.txt