id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-336561-llwjsds8	Ghosh, Sanhita	siRNA could be a potential therapy for COVID-19	2020-04-22		.txt	text/plain	743	51	60	Thus, the sequence coding for nsp5 can be treated as a potential target for RNAi using siRNA based therapeutics. Further, Alnylam Pharmaceuticals (USA) has designed and synthesized over 350 siRNA targeting highly conserved regions of the available SARS-CoV-2 genome (Hodgson, 2020) . In this context, Conti and co-researchers have demonstrated an in vitro testing of poly (amidoamine) dendrimer nanocarriers for the potential aerosol-based delivery system of siRNA onto lung epithelial cells (Conti et al., 2014) . Thus, for the treatment of COVID-19 siRNA based therapy can be developed against the novel coronavirus SARS-CoV-2, where siRNAs can hit the highly conserved region of SARS-CoV-2 RNA and also can act as an inhibitor to suppress the genetic disorders of the lungs. The cytopathic effect (CPE) was observed in Vero cells when it was infected with SARS and reduced the CPE after siRNA treatment. Research and development on therapeutic agents and vaccines for COVID-19 and related human coronavirus diseases	./cache/cord-336561-llwjsds8.txt	./txt/cord-336561-llwjsds8.txt