id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-336066-n9yq8enz	Lai, Chien‐Chen	Proteomic analysis of up‐regulated proteins in human promonocyte cells expressing severe acute respiratory syndrome coronavirus 3C‐like protease	2007-04-04		.txt	text/plain	4014	213	45	Functional classification of identified up-regulated proteins indicated that protein metabolism and modification, particularly in the ubiquitin proteasome pathway, was the main biological process occurring in SARS CoV 3CLpro-expressing cells. Interestingly, analysis of apoptosis signaling pathway revealed that the mitochondrial apoptogenic apoptosisinducing factor (Spot ID 55) was up-regulated and antiapoptogenic heat shock cognate 71-kDa protein (HSP70) (Spot ID 83) was down-regulated in 3CLpro-expressing cells (Table 3 ). Confocal imaging of the stained cells revealed that the release of apoptosis-inducing factor from mitochondria was found in the SARS CoV 3CLpro-expressing cells (Fig. 7A, right) , but not in mock cells (Fig. 7A, left) . Interestingly, analysis of the apoptosis signaling pathway revealed that the mitochondrial apoptogenic apoptosisinducing factor (Spot ID 55) was up-regulated and antiapoptogenic heat shock cognate 71-kDa protein (HSP70) (Spot ID 83) was down-regulated in 3CLpro-expressing cells (Figs.	./cache/cord-336066-n9yq8enz.txt	./txt/cord-336066-n9yq8enz.txt