id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-335292-x2vjzp18	Nagashima, S.	The Endothelial Dysfunction and Pyroptosis Driving the SARS-CoV-2 Immune-Thrombosis	2020-06-19		.txt	text/plain	3502	221	43	Approach and Results: Post-mortem lung (6 cases of COVID-19 group; 10 cases of H1N1 group and 11 cases of Control group) and myocardial samples (2 cases of COVID-19 and one control) were analyzed by conventional immunohistochemistry by using antibodies to identify molecules involving with endothelial activation (CD163, Interleukin-6 (IL-6), Tumor Necrosis Factor alpha (TNF-alpha), Intercellular Adhesion Molecule 1 (ICAM-1)) and pyroptosis (Caspase-1). In addition to COVID-19 endothelial activation, the probable higher significant involvement of pyroptosis, in this pandemic disease, but not in H1N1pdm09, may drive the massive endothelial cell death contributing to thrombogenic mechanism. The presence of the same pattern of tissue expression (COVID-19 patients with higher CD163, IL-6, ICAM-1, TNF-alpha, and Caspase-1 tissue expression than control patient) in the myocardial samples might suggest that endothelial dysfunction and pyroptosis mechanism could be more than a local lung process, but a systemic event.	./cache/cord-335292-x2vjzp18.txt	./txt/cord-335292-x2vjzp18.txt