id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-334858-wxexl0qy	Lozada-Nur, Francina	Dysgeusia in COVID-19: possible mechanisms and implications	2020-06-27		.txt	text/plain	1839	113	50	A European multi-center epidemiological study 6 analyzing the prevalence of olfactory and gustatory dysfunctions as a clinical presentation in a cohort of 417 laboratory-confirmed cases of COVID-19 with mild-to-moderate disease presentation reported that 88.8% of patients population had gustatory disorders. 18, 19 It may be quite plausible that SARS-Cov-2 binds to ACE2 receptors present in oral mucosa, triggering an inflammatory response that leads to cellular and genetic changes which could alter taste. It is possible that zinc chelation through immune mechanisms and molecules known to increase in concentration with inflammatory processes may result in acute hypozincemia 27 or a more localized change in cellular zinc homeostasis of oral gustatory cells due to infection with SARS-Cov-2. We hypothesize that changes in localized cellular zinc homeostasis in oral gustatory cells due to immune responses to SARS-Cov-2 viral replication, may result in dysgeusia which may or may not be accompanied by hypozincemia.	./cache/cord-334858-wxexl0qy.txt	./txt/cord-334858-wxexl0qy.txt