id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-334378-dqtnj3y3	Zhang, Yi	Molecular structure analyses suggest strategies to therapeutically target SARS-CoV-2	2020-06-10		.txt	text/plain	1452	86	55	How does RBD of the SARS-CoV-2 spike protein binds to the human receptor ACE2? The precise binding interface of the SARS-CoV-2 spike RBD and ACE2 can be dissected from the crystal structures of the complex determined by Shang et al. Analysis of the crystal structures of RBD from the SARS-CoV spike protein in complex with established SARS-CoV neutralizing human m396 and 80R antibodies reveals that the antibodies are bound in the same binding site as ACE2 9,10 , implying that their neutralizing mechanism is a direct blockage of receptor binding. Proteolytic cleavage of the SARS-CoV-2 spike protein by the human serine protease TMPRSS2 is a critical step in the virus entry through the plasma membrane fusion mechanism (Fig. 2) , as shown by Hoffmann et al. In addition to targeting components of the viral attachment and the membrane fusion machinery, other strategies to eliminate SARS-CoV-2 include impeding virus entry into the host cell through the endosomal pathway and disrupting activities of viral proteins.	./cache/cord-334378-dqtnj3y3.txt	./txt/cord-334378-dqtnj3y3.txt