id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-333713-nz36i2oa	Andonegui-Elguera, Sergio	Molecular Alterations Prompted by SARS-CoV-2 Infection: Induction of Hyaluronan, Glycosaminoglycan and Mucopolysaccharide Metabolism	2020-06-18		.txt	text/plain	1729	88	37	Results Alterations in genes involved in hyaluronan, glycosaminoglycan and mucopolysaccharides metabolism were over-represented in bronchoalveolar cells infected by SARS-CoV-2, as well as potential lung infiltration with neutrophils, NK cells, T CD4+ cell and macrophages. Conclusions In summary our results revealed molecular pathogenesis of the SARS-CoV-2 infection to bronchoalveolar cells inducing the hyaluronan and glycosaminoglycan metabolism that could shape partially the components of the ground-glass opacities observed in CT. Therefore, in the present work we carried out comprehensive and stringent transcriptomic metanalysis of SARS-CoV-2 infected bronchoalveolar cells and peripheral blood mononuclear cells to unveil the molecular alterations caused by viral infection as well as deconvolution analysis to identify the immune cell profiles in COVID-19 patients. Using molecular deconvolution analysis, we identified the presence of neutrophils, NK cells, T CD4+ lymphocytes and macrophages infiltrating the lungs of COVID-19 patients, consistently our findings with the previously reported (14) .	./cache/cord-333713-nz36i2oa.txt	./txt/cord-333713-nz36i2oa.txt