id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-332555-jfqlkd72	Du, Hengzhi	The potential effects of DPP‐4 inhibitors on cardiovascular system in COVID‐19 patients	2020-07-26		.txt	text/plain	1411	96	41	similar outer membrane spike glycoproteins among the coronavirus, it is possible that DPP-4 might also be a functional receptor of SARS-CoV-2. It has been reported that membrane-associated human DPP-4, as a functional MERS-CoV receptor, interacted with MERS-CoV through the spike glycoprotein S1b domain to facilitate the entry of MERS-CoV. Evidence from severely ill patients with COVID-19 suggested that the release of cytokines and chemokines was delayed in respiratory epithelial cells, dendritic cells (DCs) and macrophages at the early stage of SARS-CoV-2 infection. 17 Similar findings were also observed in SARS-CoV and MERS-CoV infected human airway epithelial cells, THP-1 cells, human peripheral blood monocyte-derived macrophages and DCs. 18 Although inflammation initially only damages limited organs, such as the lungs, an over-activated inflammatory response will spread all over the body rapidly, including the heart. Meanwhile, DPP-4 inhibitors could inhibit the over-activated inflammatory caused by SARS-CoV-2 and thus improve cardiovascular function. The potential effects of DPP-4 inhibitors on cardiovascular system in COVID-19 patients	./cache/cord-332555-jfqlkd72.txt	./txt/cord-332555-jfqlkd72.txt