id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-330121-eadu2ba3	Gudmundsdottir, Ágústa	Inactivation of SARS‐CoV‐2 and HCoV‐229E in vitro by ColdZyme® a medical device mouth spray against common cold	2020-09-25		.txt	text/plain	1628	114	58	It contains glycerol and minor amounts of purified cold-adapted trypsin 5 The entry of coronaviruses into host cells is mediated by the spike (S) glycoprotein that forms homo-trimers protruding from the virus surface 11 . Based on the results presented in this study, CZ-MD was found to inactivate SARS-CoV-2 (98.3%) and HCoV-229E (99.9%) in vitro (Table I) Coronaviruses cause about one-third of the common cold cases 4 Entry of coronaviruses into susceptible cells requires receptor-binding of the S protein and it's proteolytic processing by host cell proteases that occurs in a concerted action to promote virus-cell fusion 3 . However, the in vitro study presented here clearly demonstrates that the CZ-MD (containing cod trypsin) inactivates SARS-CoV-2 and HCoV-229E. Although the in vitro results presented cannot be directly translated into clinical efficacy, the study indicates that CZ-MD might offer a protective barrier against coronaviruses such as SARS-CoV-2 and a decreased risk of COVID-19 transmission.	./cache/cord-330121-eadu2ba3.txt	./txt/cord-330121-eadu2ba3.txt