id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-329825-e9mepqvn	Giamarellos-Bourboulis, Evangelos J.	Complex Immune Dysregulation in COVID-19 Patients with Severe Respiratory Failure	2020-04-21		.txt	text/plain	3756	177	47	Immune responses of critically ill patients with sepsis can be classified into three patterns: macrophage-activation syndrome (MAS) (Kyriazopoulou et al., 2017) , sepsis-induced immunoparalysis characterized by low expression of the human leukocyte antigen D related (HLA-DR) on CD14 monocytes (Lukaszewicz et al., 2009) , and an intermediate functional state of the immune system lacking obvious dysregulation. Abbreviations are as follows: ALT, alanine aminotransferase; aPTT, activated partial thromboplastin time; AST, aspartate aminotransferase; APACHE, acute physiology and chronic health evaluation; CCI, Charlson's comorbidity index; INR, international normalized ratio; PSI, pneumonia severity index; SD, standard deviation; SOFA, sequential organ failure assessment Immune classification of patients with SARS-CoV-2 was performed by using the tools suggested for bacterial sepsis, i.e., ferritin more than 4,420 ng/mL for MAS (Kyriazopoulou et al., 2017) , and HLA-DR molecules on CD14 monocytes lower than 5,000, in the absence of elevated ferritin, for the immune dysregulation phenotype (Lukaszewicz et al., 2009) .	./cache/cord-329825-e9mepqvn.txt	./txt/cord-329825-e9mepqvn.txt