id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-329200-o5hxpl8f	Houlihan, Catherine F	The complexities of SARS-CoV-2 serology	2020-09-23		.txt	text/plain	1010	60	40	Our understanding of individual and population-level immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains incomplete and developing reliable serological assays to detect previous infection has been an intense focus of the global scientific effort. For public health planning we need scalable assays validated against large banks of samples from individuals who had proven seasonal (non-severe acute respiratory syndrome) coronaviruses and those who had well characterised symptomatic and asymptomatic confirmed SARS-CoV-2 infection. In The Lancet Infectious Diseases, the National SARS-CoV-2 Serology Assay Evaluation Group 1 provide the first large comparative investigation of the performance of four widely available commercial assays and a single in-house assay. Antibody responses to SARS-CoV-2 are predominantly directed at the spike glycoprotein, which the virus requires for entry, and the nucleocapsid protein, which binds the viral RNA genome. 2,3 The DiaSorin, Siemens, and in-house assays measured these potentially protective antibodies, with the inhouse ELISA using trimerised spike protein, which shows a high correlation with neutralisation.	./cache/cord-329200-o5hxpl8f.txt	./txt/cord-329200-o5hxpl8f.txt