id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-329186-0eoz4npg	Xia, Shuai	The role of furin cleavage site in SARS-CoV-2 spike protein-mediated membrane fusion in the presence or absence of trypsin	2020-06-12		.txt	text/plain	1742	112	64	title: The role of furin cleavage site in SARS-CoV-2 spike protein-mediated membrane fusion in the presence or absence of trypsin It has been speculated that RRAR, a unique furin-like cleavage site (FCS) in the spike protein (S), which is absent in other lineage B βCoVs, such as SARS-CoV, is responsible for its high infectivity and transmissibility. Then, by calculating the ratio of the fused cells, we can assess the fusogenic capacity of the S protein in the presence or absence of exogenous trypsin or human airway trypsin-like protease (HAT). Next, we compared the fusogenic capacity of SARS-CoV-2-S, SARS-CoV-S and their mutants via an S-mediated cell-cell fusion assay in the absence of exogenous trypsin or human airway trypsin-like protease (HAT). © The Author(s) 2020 Fig. 1 The function of furin cleavage site in SARS-CoV-2-S mediated fusion. Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion	./cache/cord-329186-0eoz4npg.txt	./txt/cord-329186-0eoz4npg.txt