id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-328853-0iqdqcp6	Neidleman, Jason	SARS-CoV-2-specific T cells exhibit phenotypic features of robust helper function, lack of terminal differentiation, and high proliferative potential	2020-08-19		.txt	text/plain	2431	133	52	title: SARS-CoV-2-specific T cells exhibit phenotypic features of robust helper function, lack of terminal differentiation, and high proliferative potential SUMMARY Convalescing COVID-19 patients mount robust T cell responses against SARS-CoV-2, suggesting an important role for T cells in viral clearance. Our results suggest that long-lived and robust T cell immunity is generated following natural SARS-CoV-2 infection, and support an important role for SARS-CoV-2-specific T cells in host control of COVID-19. Furthermore, the clonality of T cell receptor (TCR) sequences 54 5 is higher in patients with mild rather than severe COVID-19, suggesting a role for antigen-55 specific T cell responses in symptom resolution. We report here that SARS-CoV-2-specific CD4+ and CD8+ T cells from convalescent 86 individuals are diverse, exhibit features different from antigen-specific T cells against CMV, 87 include cells with both lymphoid and tissue homing potential, harbor phenotypic features of 88 functional effector cells, and are long-lived and capable of homeostatic proliferation.	./cache/cord-328853-0iqdqcp6.txt	./txt/cord-328853-0iqdqcp6.txt