id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-328325-yonbkrwe	Nielsen, Sandra C. A.	B cell clonal expansion and convergent antibody responses to SARS-CoV-2	2020-05-06		.txt	text/plain	3377	180	57	Here we show that the human B cell compartment in patients with diagnostically confirmed SARS-CoV-2 and clinical COVID-19 is rapidly altered with the early recruitment of B cells expressing a limited subset of V genes, and extensive activation of IgG and IgA subclasses without significant somatic mutation. We detect expansion of B cell clones as well as convergent antibodies with highly similar sequences across SARS-CoV-2 patients, highlighting stereotyped naïve responses to this virus. We detect expansion of B cell clones as well as convergent antibodies with highly similar sequences across SARS-CoV-2 patients, highlighting stereotyped naïve responses to this virus. Sequences convergent to known SARS-CoV-speci c antibody IGH sequences13 were identi ed in one COVID-19 patient (7453-D2) but were not detected in the HHC samples (Fig. 4c) .	./cache/cord-328325-yonbkrwe.txt	./txt/cord-328325-yonbkrwe.txt