id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-328122-nfvbog77	Tresoldi, Ilaria	SARS‐COV‐2 and infectivity: Possible increase in infectivity associated to integrin motif expression	2020-04-10		.txt	text/plain	698	48	48	It has been proposed that SARS-COV-2 has acquired the spike glycoprotein RGD (KGD in SARS-CoV) 1 integrin-binding site which is considered significant for the virus transmission efficiency. The most common of these motifs is the minimal peptide sequence for binding integrins, RGD, which is known for its role in virus infection via its ability to interact with over half of the more than 20 known integrins. 4 Besides the fibronectin binding motif RGD, other integrinbinding sites are specifically expressed in SARS-COV-2, and, particularly, a change from a LDV to a LDI motif is likely significant. 5 We investigated the protein sequence of the human coronavirus and compared it to SARS and bat coronavirus to identify any eventual overexpression of other integrin-binding sites. Orf1ab polyprotein has many integrin-binding motifs implicated in cell adhesion with binding sites on Fibronectin, Tenascin_C, and VCAM.	./cache/cord-328122-nfvbog77.txt	./txt/cord-328122-nfvbog77.txt