id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-327616-uu9uygic	Wazny, Vanessa	Vascular underpinning of COVID-19	2020-08-27		.txt	text/plain	6970	359	33	Coronavirus disease 2019 (COVID-19) case study reports have called attention to the overrepresentation of cardiovascular diseases, in addition to respiratory diseases, among patients at risk of critical illness and mortality following severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection [1] [2] [3] [4] [5] [6] [7] [8] . Initial concerns were also raised regarding the medical treatment of hypertension with adverse COVID-19 outcomes, as studies in animals have shown that the use of renin-angiotensin system blockers-angiotensin-converting enzyme inhibitors and angiotensin receptor blockers result in the upregulation of angiotensin-converting enzyme 2 (ACE2) expression, which is an entry factor for SARS-CoV-2 [13] . Collectively, these case reports of confirmed COVID-19 hospitalized patients strongly indicate a strong association between underlying cardiovascular diseases and diabetes with severe health outcomes and fatality following SARS-CoV-2 infection. In COVID-19 research, nasal and alveolar epithelial cells are generally believed to be the primary sites of viral infection due to the high expressions of SARS-CoV-2 entry factors [51] .	./cache/cord-327616-uu9uygic.txt	./txt/cord-327616-uu9uygic.txt