id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-327459-tyhy784d	Gómez-Rial, J.	A strategy targeting monocyte-macrophage differentiation to avoid pulmonary complications in SARS-Cov2 infection	2020-04-23		.txt	text/plain	785	51	35	Gómez-Rial J, MD 1,2 , Martinón-Torres F, MD, Phd, Assoc Prof 1 The immune dysregulation and cytokine storm observed in severe COVID-19 cases has led to the trial of licensed RA drugs such as Chloroquine, IL-1/IL-6 blockers, TNF or Janus kinase inhibitors in COVID-19 patients [1] In addition we propose that blockade of granulocyte macrophage-colony stimulating factor (GM-CSF) may be an effective strategy to prevent pulmonary complications and fatality in SARS-Cov2 infection. and inflammation-related phenotypic changes in peripheral blood monocytes, and correlation with acute respiratory distress syndrome (ARDS) in severe patients [5] Furthermore, single-cell RNA sequencing of lung bronchoalveolar immune cells infection [6] If these findings are confirmed, they would indicate that in SARS-Cov2, similarly to SARS-Cov1, acute lethal disease is produced by delayed and dysregulated type I interferon response and pulmonary accumulation of inflammatory monocytemacrophages, which are mainly responsible for immunopathology [6, 7] .	./cache/cord-327459-tyhy784d.txt	./txt/cord-327459-tyhy784d.txt