id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-326305-mjd5agvf	Ashraf, Mohammad Ali	The application of direct viral cytopathic hypothesis to design drug trials in the battle against COVID-19	2020-08-15		.txt	text/plain	1109	68	44	As previously shown, clathrin-mediated endocytosis is the main pathway for virus entry, while doublemembrane vesicles formation and autophagy in the host cell is the mechanism for viral replication [14] . Imatinib, a protein-tyrosine kinase inhibitor that inhibits the BCR-ABL tyrosine kinase which is approved to treat chronic myeloid leukemia by inhibiting ABL oncogenetic pathway has previously shown success in disrupting the viral entry mechanism of both SARS-CoVand MERS-CoV into the cell; hence, it can also be considered as a potentially useful drug to treat patients with severe forms of COVID-19. Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor	./cache/cord-326305-mjd5agvf.txt	./txt/cord-326305-mjd5agvf.txt