id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-326273-6rp12py3	Chow, Kuan-Chih	Detection of Severe Acute Respiratory Syndrome–Associated Coronavirus in Pneumocytes of the Lung	2004-04-01		.txt	text/plain	3202	190	45	Previous reports have indicated that patients with severe acute respiratory syndrome (SARS)–associated coronavirus infection could develop atypical pneumonia with fulminant pulmonary edema. Severe acute respiratory syndrome (SARS) is an acute infectious disease that affects primarily the lower respiratory tract, with clinical manifestations of atypical pneumonia with dry cough, persistent fever, progressive dyspnea, and, sometimes, the abrupt deterioration of lung function [1] [2] [3] [4] [5] and the ensuing oxygen deprivation-associated systemic organ failures. Nevertheless, when antisense oligonucleotide probes specific to the replicase-encoding (REP) region of the SARS viral genome were used to determine the presence of virus, the intensity of the in situ hybridization signal decreased substantially compared with that detected by probes to the N and M regions ❚Image 2D❚ ❚Table 3❚. B, By using in situ hybridization and antisense oligonucleotide probes specific to the nucleic acid binding protein-encoding (N) and membrane protein-encoding (M) regions of the severe acute respiratory syndrome (SARS) viral genome, the SARS viral signal was detected in the enlarged and multinucleated cell (arrow, purple blue precipitates).	./cache/cord-326273-6rp12py3.txt	./txt/cord-326273-6rp12py3.txt