id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-325595-y9ae6zbr	Montopoli, M.	Genetic and hormonal influence on SARS-CoV-2-infection susceptibility: Re: The potential influence of human Y-chromosome haplogroup on COVID-19 prevalence and mortality	2020-10-23		.txt	text/plain	1251	72	46	title: Genetic and hormonal influence on SARS-CoV-2-infection susceptibility: Re: The potential influence of human Y-chromosome haplogroup on COVID-19 prevalence and mortality in the Annals of Oncology reported findings congruent with the prevailing notion that high SARS-CoV-2 infection rates and disease severity in men may be the result of high androgen-driven TMPRSS2 expression in the lungs. The authors posit that since TMPRSS2 is under positive transcriptional control by the androgen receptor (AR), reduction of TMPRSS2 expression following androgen deprivation therapy (ADT) in prostate cancer patients would be expected to correlate with reduced SARS-CoV-2 incidence, and in case of infection, with lesser disease severity. In particular, disease stage and the type of treatment that may affect AR or TMPRSS2 expression and/or patients' The current thinking posits that under ADT, expression of TMPRSS2 (a co-factor for SARS-CoV-2 activation and virulence) would be reduced in the lungs, leading to less severe disease, hospitalizations, ICU admissions, and deaths.	./cache/cord-325595-y9ae6zbr.txt	./txt/cord-325595-y9ae6zbr.txt