id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-325460-4fhegc0z	Jacobs, Werner	Fatal lymphocytic cardiac damage in coronavirus disease 2019 (COVID‐19): autopsy reveals a ferroptosis signature	2020-09-22		.txt	text/plain	3977	241	39	Immunohistochemical staining with E06, a monoclonal antibody binding to oxidized phosphatidylcholine (reflecting lipid peroxidation during ferroptosis), was positive in morphologically degenerating and necrotic cardiomyocytes adjacent to the infiltrate of lymphocytes, near arteries, in the epicardium and myocardium. We examined the patient's myocardial tissue for markers of ferroptosis, an iron-catalysed form of regulated cell death that occurs through excessive peroxidation of polyunsaturated fatty acids and is also proposed to detrimentally contribute to some forms of ischaemia-reperfusion injury, stroke, and degenerative diseases. Renal tissue from the COVID-19 patient with myocarditis and multiple organ dysfunction syndrome showed morphological signs of acute tubular necrosis, intratubular oxalate crystals, as well as E06 positivity in proximal tubuli (A). By comparison, in the case of sudden death due to myocarditis of other aetiology, immunohistochemical staining with E06 (B) and anti-4-HNE antibody (D) in the renal tissue showed no presence of these ferroptosis markers (non-specific staining in the corticomedullary junction is also present on control stains).	./cache/cord-325460-4fhegc0z.txt	./txt/cord-325460-4fhegc0z.txt