id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-325449-fl6ob5ja	Wang, Jing	COVID-19 and diabetes: the contributions of hyperglycemia	2020-10-01		.txt	text/plain	3424	164	42	Thus, following SARS-CoV-2 infection, poor-controlled blood glucose in diabetes patients may promote macrophage inflammation and antigen presentation impairment in DCs, resulting in a great increase in the secretion of inflammatory cytokines and chemokines from immune cells and ultimately cytokine storm and increased mortality (Figure 1) . The exact mechanisms linking diabetes and COVID-19 remain to be further elucidated, but available clinical/laboratory observations suggest that hyperglycemia-induced immune dysfunction, cytokines storm, and elevated lactate levels may play critical roles in the severity of COVID-19 in patients with pre-existing diabetes. A large body of evidence shows that hyperglycemia or diabetes may impair immune response mediated by macrophages, monocytes, and DCs, weaken T-cell function, and promote cytokine storm, ultimately resulting in increased susceptibility of SARS-CoV-2 infection and COVID-19-associated mortality. Hyperglycemia may also increase lactate production via HIF-1α, which suppresses the innate immune RLR signaling by targeting MAVS, leading to delayed clearance of SARS-CoV-2 and thus severe outcomes in diabetes patients with COVID-19, including ARDS, septic shock, and MODS.	./cache/cord-325449-fl6ob5ja.txt	./txt/cord-325449-fl6ob5ja.txt