id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-324926-3c5ab73l	Xia, Shuai	A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike	2019-04-10		.txt	text/plain	10849	515	55	Therefore, it is reasonable to speculate that HR1 could also be a good target for the development of fusion inhibitors against highly pathogenic HCoVs. We and others have reported that peptides derived from the HR2 regions of SARS-CoV and MERS-CoV S proteins can competitively inhibit viral 6-HB formation, thereby preventing viral fusion and entry into host cells (18, 27) . Moreover, structural studies of EK1 in complex with HR1s from different HCoVs explain the conserved basis for the HR1-EK1 interaction, further indicating that HR1 region could serve as a promising target site for the development of broad-spectrum pan-CoV fusion inhibitors. On the other hand, HR2P peptides derived from the two -HCoVs, i.e., 229E and NL63, showed potent and broad inhibitory activity against -HCoV S-mediated cell-cell fusion with IC 50 values ranging from 0.13 to 0.51 M or from 0.21 to 0.56 M, respectively, but no effective inhibitory activity against -HCoVs (including MERS-CoV, SARS-CoV, and OC43) S-mediated fusion ( Fig. 1D and table S1 ).	./cache/cord-324926-3c5ab73l.txt	./txt/cord-324926-3c5ab73l.txt