id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-323105-gqqzekfk	Lin, Chen-Si	Enhancement of anti-murine colon cancer immunity by fusion of a SARS fragment to a low-immunogenic carcinoembryonic antigen	2012-02-03		.txt	text/plain	3208	153	46	Oral vaccination of an attenuated Salmonella typhimurium strain transformed with plasmids encoding CEA-SARS-CoV fusion gene into BALB/c mice elicited significant increases in TNF-α and IL-10 in the serum. For achieving simple administration of drugs and enhancement of host immunity, an oral DNA vaccine vector, Salmonella typhimurium (SL3261) [7] , was used as a carrier to deliver the SARS-CoV-CEA fusion genes. By combining SARS-CoV epitope, a tumor unrelated antigenic fragment, with CEA, we finally demonstrated this could be a promising anti-cancer strategy through effectively increasing both Th1 and Th2 cytokines and decreasing tumor volume. In comparison with the negative control group, no significant differences in tumor volume were observed in mice immunized with CEA alone, while the tumor volume was found to be smaller in the pCEA-SARS-CoV group in the protection and therapy assays (Figure 3 &4) .	./cache/cord-323105-gqqzekfk.txt	./txt/cord-323105-gqqzekfk.txt