id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-323094-zugrtvyo	Rose, R.	Intra-host site-specific polymorphisms of SARS-CoV-2 is consistent across multiple samples and methodologies	2020-04-29		.txt	text/plain	1774	119	58	Here, we quantify and characterize intra-host variation in SARS-CoV-2 raw sequence data uploaded to SRA as of 14 April 2020, and compare results between two sequencing methods (amplicon and RNA-Seq). While mutations resulting from amplification and/or sequencing errors cannot be excluded, the observation of shared polymorphic sites with high MAF across multiple samples and sequencing methods is consistent with true underlying variation. Our goal in this study was to quantify and characterize intra-host variation in all SARS-CoV-2 raw sequence data available in SRA as of 14 April 2020, and compare results between two All rights reserved. . https://doi.org/10.1101/2020.04.24.20078691 doi: medRxiv preprint 5 percent of the genome covered at 10x and 25x remained high with the amplicon data (10x IQR: 0.987 -0.997; 25x IQR: 0.980 -0.997), the range was much broader for the RNA-Seq data (10x IQR: 0.240 -0.997; 25x IQR: 0.024 -0.993).	./cache/cord-323094-zugrtvyo.txt	./txt/cord-323094-zugrtvyo.txt