id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-322807-b24ujorz	Koyama, Takahiko	Emergence of Drift Variants That May Affect COVID-19 Vaccine Development and Antibody Treatment	2020-04-26		.txt	text/plain	1869	95	50	The coronavirus genome is highly prone to mutations that lead to genetic drift and escape from immune recognition; thus, it is imperative that sub-strains with different mutations are also accounted for during vaccine development. Typically, surface proteins outside of the viral virion are selected for antigens so that antibodies generated from a vaccine-trained B-cell can bind to the virus for neutralization. This study's objective is to interrogate currently identified sub-strains of SARS-CoV-2 and identify genetic drifts and potential immune recognition escape sites that would be integral for the development of a successful vaccine. In these countries, the majority of infected patients possess the variant; therefore, vaccine design and convalescent plasma antibody treatment might require further considerations to accommodate the drift. A spike glycoprotein peptide encompassing residues 604-625 derived from a convalescent SARS-CoV-1 patient was successfully able to elicit humoral immune response and prevent infection in non-human primates, underscoring the immunogenic importance of this region [10] .	./cache/cord-322807-b24ujorz.txt	./txt/cord-322807-b24ujorz.txt