id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-322345-rq5gh710	Zheng, Fang	A Novel Protein Drug, Novaferon, as the Potential Antiviral Drug for COVID-19	2020-04-29		.txt	text/plain	3617	205	54	We aimed to determine the anti-SARS-CoV-2 effects of Novaferon in vitro, and conducted a randomized, open-label, parallel group study to explore the antiviral effects of Novaferon for COVID-19. The primary endpoint was the SARS-CoV-2 clearance rates on day 6 of treatment, and the secondary endpoint was the time to the SARS-CoV-2 clearance in COVID-19 patients Results Novaferon inhibited the viral replication in infected cells (EC50=1.02 ng/ml), and protected healthy cells from SARS-CoV-2 infection (EC50=0.1 ng/ml). Results from the 89 enrolled COVID-19 patients showed that both Novaferon and Novaferon plus Lopinavir/Ritonavir groups had significantly higher SARS-CoV-2 clearance rates on day 6 than the Lopinavir/Ritonavir group (50.0% vs.24.1%, p = 0.0400, and 60.0% vs.24.1%, p = 0.0053). We first determined whether Novaferon was able to inhibit SARS-CoV-2 at cellular level, and then conducted a randomized, open-label, parallel group trial to explore the antiviral effects of Novaferon in patients with COVID-19 by observing the SARS-CoV-2 clearance rates at different times during the treatment period.	./cache/cord-322345-rq5gh710.txt	./txt/cord-322345-rq5gh710.txt