id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-321742-cstub5zz	Tovar, Isabel	Rationale for the Use of Radiation-Activated Mesenchymal Stromal/Stem Cells in Acute Respiratory Distress Syndrome	2020-09-02		.txt	text/plain	6896	292	36	We have previously shown that the combination of radiotherapy with human umbilical-cord-derived mesenchymal stromal/stem cells (MSCs) cell therapy significantly reduces the size of the xenotumors in mice, both in the directly irradiated tumor and in the distant nonirradiated tumor or its metastasis. Knowing the role of annexin A1 in the control of hypoxia and inflammation that is characteristic of acute respiratory-distress syndrome (ARDS), we designed a hypothetical therapeutic strategy, based on the transplantation of mesenchymal stromal/stem cells stimulated with radiation, to alleviate the symptoms of patients who, due to pneumonia caused by SARS-CoV-2, require to be admitted to an intensive care unit for patients with life-threatening conditions. Supposedly a vectorized signaling system, we now believe that the exosomes released from radiation-activated-MSCs cells can reach other organs different from the lungs, where they will be up-taken after intravenous injection and thus extend the anti-inflammatory and antimicrobiological effects of the treatment, to cover systemic problems such as the treatment of patients with septic shock in general and for COVID-19 at this particular time.	./cache/cord-321742-cstub5zz.txt	./txt/cord-321742-cstub5zz.txt