id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-321714-yhruzu7f	Ryu, Young Bae	SARS-CoV 3CL(pro) inhibitory effects of quinone-methide triterpenes from Tripterygium regelii	2010-03-15		.txt	text/plain	1933	114	59	Isolated quinone-methide triterpenes (1-4) and 5 were evaluated for SARS-CoV 3CL pro inhibitory activities and showed potent inhibitory activities with IC 50 values of 10.3, 5.5, 9.9 , and 2.6 lM, respectively, whereas the corresponding 5 having phenol moiety was observed in low activity (IC 50 = 21.7 lM). Isolated quinone-methide triterpenes (1-4) and 5 were evaluated for SARS-CoV 3CL pro inhibitory activities and showed potent inhibitory activities with IC 50 values of 10.3, 5.5, 9.9 , and 2.6 lM, respectively, whereas the corresponding 5 having phenol moiety was observed in low activity (IC 50 = 21.7 lM). We then further characterized the inhibitory mechanism of the isolated quinone-methide triterpenes against SARS-CoV 3CL pro activity. Although all isolated quinone-methide triterpenes has previously been known compounds, this is the first time it has been shown to possess SARS-CoV 3CL pro inhibitory activity.	./cache/cord-321714-yhruzu7f.txt	./txt/cord-321714-yhruzu7f.txt