id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-321308-rwxhdg8r	Grubaugh, Nathan D.	Making sense of mutation: what D614G means for the COVID-19 pandemic remains unclear	2020-07-03		.txt	text/plain	1505	87	60	While clinical and in vitro data suggest that D614G changes the virus phenotype, the impact of the mutation on transmission, disease, and vaccine and therapeutic development are largely unknown. Following the emergence of SARS-CoV-2 in China in late 2019, and the rapid expansion of the COVID-19 pandemic in 2020, questions about viral evolution have come tumbling after. They present compelling data that an amino acid change in the virus' spike protein, D614G, emerged early during the pandemic, and viruses containing G614 are now dominant in many places around the world. In support of their hypothesis, the authors provided evidence that clinical samples from G614 infections have a higher levels of viral RNA, and produced higher titers in pseudoviruses from in vitro experiments; results that now seem to be corroborated by others [e.g. Tracking changes in SARS-CoV-2 Spike: evidence that D614G increases infectivity of the COVID-19 virus Naturally mutated spike proteins of SARS-CoV-2 variants show differential levels of cell entry	./cache/cord-321308-rwxhdg8r.txt	./txt/cord-321308-rwxhdg8r.txt