id author title date pages extension mime words sentences flesch summary cache txt cord-320848-bz9pf2p6 Sepehrinezhad, Ali COVID-19 virus may have neuroinvasive potential and cause neurological complications: a perspective review 2020-05-16 .txt text/plain 2758 186 52 Here, we reviewed the evidence of the neuroinvasive potential of coronaviruses and discussed the possible pathogenic processes in CNS infection by COVID-19 to provide a precise insight for future studies. Therefore, the aim of the present study was to review neuroinvasive potential and neurotropism effects of human coronaviruses (HCoVs) and discuss the probable neurological complication followed by COVID-19 to give an insight for future studies. We used the terms "coronavirus," "SARS," "SARS-CoV-2," "MERS," "229E-CoV," and "COVID-19," w i t h c o m bi n a t i o n th e t e r m s " n er vo us sy s t e m , " "neuroinvasion," and "neurological manifestation." In vitro studies on neurotropism potentials of CoVs on neural or glial cells cultures were considered. Severe acute respiratory syndrome coronavirus infection causes neuronal death in the absence of encephalitis in mice transgenic for human ACE2 ./cache/cord-320848-bz9pf2p6.txt ./txt/cord-320848-bz9pf2p6.txt